We are investigating the function of FGF receptor signaling in specific cardiovascular lineages. We have shown that endothelial FGF receptor signaling is essential for wound healing, and the hearts response to ischemia-reperfusion injury. FGF receptors are being targeted in cardiomyocytes and stromal cells of the heart and other tissues to address their role in tissue homeostasis, and ischemia-reperfusion injury.
1. Cilvik SN, Wang JI, Lavine KJ, Uchida K, Castro A, Gierasch CM, . . . Ornitz DM (2013) Fibroblast growth factor receptor 1 signaling in adult cardiomyocytes increases contractility and results in a hypertrophic cardiomyopathy. PLoS One 8(12):e82979. PMCID: PMC3859602.
2. Oladipupo SS, Smith C, Santeford A, Park C, Sene A, Wiley LA, . . . Ornitz DM (2014) Endothelial cell FGF signaling is required for injury response but not for vascular homeostasis. Proc Natl Acad Sci U S A 111(37):13379-13384. PMCID: PMC4169958.
3. House SL, Wang J, Castro AM, Weinheimer C, Kovacs A & Ornitz DM (2015) Fibroblast growth factor 2 is an essential cardioprotective factor in a closed-chest model of cardiac ischemia-reperfusion injury. Physiological reports 3(1):e12278-e12278. PMCID: PMC4387743.
4. House SL, Castro AM, Lupu TS, Weinheimer C, Smith C, Kovacs A & Ornitz DM (2016) Endothelial fibroblast growth factor receptor signaling is required for vascular remodeling following cardiac ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol 310(5):H559-571. PMCID: PMC4796602.