David M. Ornitz,
M.D., Ph.D.

Alumni Endowed Professor

Department of Developmental Biology

Washington University
School of Medicine

Campus Box 8103
660 South Euclid Avenue
Saint Louis, MO
63110

dornitz@wustl.edu

Ornitz DBBS Profile

Advanced Genetics I-2010

Advanced Genetics II-2010

Laboratory Members

Contact Information

DBBS


More information about David Ornitz and his laboratory: bio sketch, research interests, selected publications and laboratory resources.


Selected laboratory protocols, such as: alkaline plasmid prep, BrdU immunohistochemistry, LacZ embryo staining, RNase protection assay and many others.



Information and graphics concerning fibroblast growth factor research, such as: FGF family tree, FGFR mutations, FGF specificity data and more.


Neurobiology and the function of Intracellular FGFs(iFGFs): Intracellular Fibroblast Growth Factors (iFGFs) are important regulators of the activity of many different neurons in the brain and throughout the body

eardevtab

Regulation of cochlear development and regeneration by Fibroblast Growth Factor 20. We have identified FGF20 as an essential signal that regulates the development of sensory receptors in the inner ear. Mice lacking FGF20 are viable, healthy and congenitally deaf.

skeletal2

Many of the human craniosynostosis and chondrodysplasia syndromes are caused by missense mutations in the genes encoding FGF receptors (FGFRs) 1, 2 and 3.

cardio

Fibroblast Growth Factors (FGFs) have been proposed as important regulators of growth and function of the heart and as important angiogenic factors.

lung bio

Mice lacking FGF9 have defects in lung branching and lung mesoderm proliferation. These mice also have a male to female sex reversal secondary to decreased growth of testicular mesenchyme and failure of normal Sertoli and Lydig cell development.

Links to other programs within the School of Medicine, and to other areas of interest.

Laboratory Members, Alumni and Contact Information

 


Latest update to this page: May 13, 2014 .